The US National Institutes of Health (NIH) should dismantle a decades-old colony of 360 chimpanzees, retiring all but roughly 50 of the animals to a national sanctuary, the biomedical agency was told on 22 January in a long-awaited report.
The report, from a working group of external agency advisors, also counsels the NIH to end about half of 21 existing biomedical and behavioral experiments, saying they do not meet criteria established in a December, 2011 Institute of Medicine (IOM) report.
“Clearly there is going to be a reduction in the use of chimpanzees in research,” says working group co-chair Kent Lloyd, the associate dean for research at the School of Veterinary Medicine at the University of California, Davis.
The report says that the NIH should begin planning sanctuary housing for the retiring animals “immediately”, and that a colony of about 50 animals would be sufficient for future research. The report also sets high hurdles for new chimpanzee experiments in the future, calling for the establishment of an independent committee that would vet individual study proposals after they first pass routine NIH scientific review. In cases where the burden on the animals is high, the benefit to humanity should have to be “very high” to pass muster with the committee, says Daniel Geschwind, the other co-chair of the working group and a geneticist at the School of Medicine at the University of California, Los Angeles.
The report suggests that three of nine ongoing invasive experiments, involving immunology and infectious diseases, could continue, because they meet the IOM criteria. These require that a study be needed for public health; that no alternative animal model exists; that performing the study in humans would be unethical; and that the animals be maintained in socially and physically appropriate habitats. The report also says that eight of 13 behavioral or comparative genomics studies could be allowed to continue, but in some cases only conditionally — meaning that funding for these experiments could not be renewed without passing the independent committee review.
The working group — a subgroup of NIH’s Council of Councils, a trans-agency advisory body — was chartered by NIH director Francis Collins one year ago to advise the agency on how to implement the recommendations of the IOM report, which found that most chimpanzee research was not necessary. Its recommendations are not binding; Collins is expected to respond to them in late March, after a 60-day period of public comment. But they signal yet another significant step in an ongoing retrenchment. Last month, the agency announced that it will retire 110 chimpanzees to the national Chimp Haven sanctuary in Keithville, Louisiana, after they had been first slated to move to an active NIH-supported research centre in San Antonio, Texas.